Humidifier disinfectant, sodium dichloroisocyanurate (NaDCC): assessment of respiratory effects to protect workers’ health

Abstract In South Korea, it has been found that biocides used to control and eliminate harmful organisms are as humidifier disinfectants cause lung disease in users. Hence, efforts have focused on studying the toxicity of workers who handle them. The purpose this study was evaluate effects inhalation exposure sodium dichloroisocyanurate (NaDCC) protect health handling NaDCC. F344 rats were exposed 0.8-, 4-, 20-mg/m 3 NaDCC for 6 h per day, 5 days week 14 days, recovery period after days. -exposure group, we observed a decrease food intake females, weight loss males, partially active thromboplastin time males females 2 weeks exposure. We noted white blood cells 4- -exposed groups. Both group 4-mg/m showed irritation larynx related test substance However, these findings not group. main target organs affected by repeated 2-week nasal cavity upper respiratory tract. No Observed Adverse Effect Level (NOAEL) considered be 0.8 mg/m because even at 4 , reversible.